Our programme of research is focused on uncovering networks involved in steroid receptor coregulator (SRCs) mediated resistance to both tamoxifen and aromatase inhibitors, and in doing so identify markers to predict endocrine sensitivity and importantly develop new therapeutic targets. Our approach is to focus on SRC-1 and take a high-level view of the problem, harnessing data from high throughput experimental methods, molecular studies, functional models and translational studies. We are capitalising on our established strengths in translational research, in particular making use of primary breast cell cultures derived from patient tumours and large clinical datasets. This allows us to model the mechanism(s) of resistance associated with SRC-1 and define new predictive markers and therapeutic targets.
