Group Leader


Professor Leonie Young founded the Endocrine Oncology Research Group in RCSI, which is focused on uncovering networks involved in SRC mediated resistance to both tamoxifen and aromatase inhibitors in breast cancer. The aim of this research is to identify markers to predict endocrine sensitivity and importantly develop new therapeutic targets. The group has capitalized on our established strengths in translational research, in particular making use of primary breast cell cultures derived from patient tumours and large clinical datasets.

In 2010, Professor Young co-founded the National Breast Cancer Bioresource, which was established to standardise the collection of breast cancer material for the designated cancer hospitals throughout Ireland. To date, in collaboration with ICORG, the Breast Cancer Bioresource has collected over 1,000 fresh frozen and serum samples from patients with corresponding clinical data.

Current Lab Members

Fiona Bane                       Research Associate

Sinead Cocchiglia             Research Associate

Lance Hudson                   Research Associate

Damir Vareslija, PhD         Postdoctoral researcher

Sara Charmsaz, PhD          Postdoctoral researcher

Brendan Ffrench, PhD       Postdoctoral researcher

Ben Doherty                       Graduate Student

Siobhan Purcell                  Graduate Student

Karen Crowley                    Graduate Student

Nicola Cosgrove                  Graduate Student

Clinical Team

Prof Arnold Hill, Surgeon

Aisling Hurley, Nurse Manager

Andrew Embley, Research Nurse

Recent Alumni

Elspeth Ward, PhD              Graduate Student

Alacoque Browne, PhD       Graduate Student

Ailis Fagan, PhD                   Postdoctoral researcher

Ricardo Marques, PhD        Postdoctoral researcher

Jean McBryan, PhD              Postdoctoral researcher

Christopher Byrne, PhD       Postdoctoral researcher