Prof Leonie Young hosted a two-day Steroid Cancer Meeting in Royal College of Surgeons in September 2016. International experts, researchers, academics and clinicians came together to discuss the latest developments in the field of breast and prostate cancer research. The meeting, kindly supported by Breast Cancer Ireland, featured an excellent line-up of speakers that presented work on the very latest in clinical and translational research.

Cancer Conference – September 19TH 2016

Steroid ‘Drivers’ and Potential ‘Putters’ in Breast Cancer

Monday 19th September

Registration       Main Hall, RCSI, 123 St Stephen’s Green                                                                                                          8.30 – 9:00

Session 1 – Albert Theatre, RCSI, NUCLEAR RECEPTORS A (Chair: TBC)


  • Steffi Oesterreich, University of Pittsburgh Cancer Institute, PA.

ER alterations in endocrine resistant breast cancer                                                                                                                           9:00 – 9:30

  • Myles Brown, Dana-Farber Cancer Institute, Boston, MA.

Hacking the Endocrine Resistance Loop                                                                                                                                      9:30 – 10:00

  • Wayne Tilley, The University of Adelaide, Adelaide, South Australia

Steroid Receptor Cross Talk in Breast Cancer: Molecular Insights and Therapeutic Implications      10:00 – 10:30

  • Jennifer Richer, University of Colorado, Denver.

Rationale for targeting AR in breast cancers resistant to anti-estrogen therapy, including TNBC    10:30 – 11:00


Tea and coffee, The Atrium, RCSI                    11:00 – 11: 30


Session 2 – Albert Theatre, RCSI, SYSTEMS CANCER (Chair: TBC)


  • Jochen Prehn, Royal College of Surgeons in Ireland, Dublin, Dublin.

Apoptosis signatures in breast cancer                                                                                                                                       11:30 – 12:00

  • Robert Clarke, Georgetown University, Washington DC.

TBC                                                                                                                                                                                                                       12:00-12.30

  • Walter Kolch, University College Dublin, Dublin

Using computational modelling as prognostic and predictive biomarkers                                                                         12:30 – 13:00


Lunch, The Atrium, RCSI            13.00 – 14.00

Session 3 – Albert Theatre, RCSI, NUCLEAR RECEPTORS B (Chair: TBC )


  • Geoffrey L. Greene , University of Chicago, Chicago, IL

Targeting ER and PR in Breast Cancer Prevention and Treatment                                                                               14:00 – 14:30

  • Marie McIlroy, Royal College of Surgeons in Ireland, Dublin

AR in endocrine resistant breast cancer                                                                                                                                     1430-15:00

  • Wilbert Zwart, Netherlands Cancer Institute, Amsterdam

Genomic crosstalk of steroid hormone receptors in male breast cancer                                                            15:00 – 15:30

  • Teresa Hickey, The University of Adelaide, Adelaide, South Australia

Hormone regulation of androgen inactivating enzymes in breast cancer                                                           15:30-16:00


Tea and coffee, The Atrium, RCSI                  16:00 – 16: 15

Session 4 – Albert Theatre, RCSI, CLINICAL TRASLATION  


  • William Gallagher, University College Dublin.                                                                                                             16:15 – 16:45

Kinases as therapeutic targets: progressing new opportunities within breast cancer subtypes

  • Christopher Sweeney, Dana-Farber Cancer Institute, Boston, MA.                                                       16:45 – 17:15

Why was chemohormonal therapy beneficial in prostate but not breast cancer

  • Bryan Hennessy, Royal College of Surgeons in Ireland. 17:15 – 17.45



Reception and Dinner, The Old Exam Hall and Board Room, RCSI              18:30

Tuesday 20th September



  • Adrian Lee, University of Pittsburgh Cancer Institute, PA.

Mutational evolution in metastatic breast cancer                                                                                                             9:00 – 9:30


  • Luca Magnani, Imperial College London, London.

Novel genetic and epigenetic mechanisms driving drug resistance in luminal breast cancer                              9:30 – 10:00


  • Rosemary O’Conner, University College Cork, Cork.

Mitochondrial protection by IGF signaling in breast cancer cells                                                                                   10:00 – 10:30


Tea and coffee, The Atrium, RCSI                  11:00 – 11: 30


  • Donal P McDonnell, Duke University School of Medicine, Durham, NC.

Targeting Hormone-regulated Pathways of Pathological Importance in Cancer                                            11:00 – 11:30

  • Suzanne Fuqua, Baylor College of Medicine, Houston, TX.

Estrogen Receptor Mutations Drive Metastasis                                                                                                                    11:30– 12:00




  • Ganesh Raj, UT Southwestern Tx.                                                                                                                                                 12:00 – 12:30

Novel approaches to targeting ER+ and ER- breast cancer


  • Carlo Palmieri, University of Liverpool, Liverpool.

Endocrine therapy: Where next?’                                                                                                                                            12:30-13:00




Lunch, The Atrium, RCSI            13.00 – 14.00


Social Activities in Dublin City (TBD) or Golf, Carton House, Maynooth, Co Kildare